Article
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.
Science advances - 1 Nov 2024
Shelton Spencer D, House Sara, Martins Nascentes Melo Luiza, Ramesh Vijayashree, Chen Zhenkang, Wei Tao, Wang Xun, Llamas Claire B, Venigalla Siva Sai Krishna, Menezes Cameron J, Allies Gabriele, Krystkiewicz Jonathan, Rösler Jonas, Meckelmann Sven W, Zhao Peihua, Rambow Florian, Schadendorf Dirk, Zhao Zhiyu, Gill Jennifer G, DeBerardinis Ralph J, Morrison Sean J, Tasdogan Alpaslan, Mishra Prashant
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are frequent in cancer, yet their precise role in cancer progression remains debated. To functionally evaluate the impact of mtDNA variants on tumor growth and metastasis, we developed an enhanced cytoplasmic hybrid (cybrid) generation protocol and established isogenic human melanoma cybrid lines with wild-type mtDNA or pathogenic mtDNA mutations with partial or complete loss...
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