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Article

Mitochondrial determinants of cancer health disparities.

Seminars in cancer biology - 1 Dec 2017

Choudhury Aaheli Roy, Singh Keshav K

Abstract excerpt

Mitochondria, which are multi-functional, have been implicated in cancer initiation, progression, and metastasis due to metabolic alterations in transformed cells. Mitochondria are involved in the generation of energy, cell growth and differentiation, cellular signaling, cell cycle control, and cell death. To date, the mitochondrial basis of cancer disparities is unknown. The goal of this review is to provide an...

Topics

Animals
Cell Nucleus
Cell Transformation, Neoplastic
Energy Metabolism
Genetic Variation
Genome
Genome, Mitochondrial
Germ Cells
Humans
Mitochondria
Mitochondrial Proteins
Neoplasms

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Identifiers

PMID: 28487205
DOI: 10.1016/j.semcancer.2017.05.001
PMCID: PMC5673596

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