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Article

Refining genome-wide associated loci for serum uric acid in individuals with African ancestry.

Human molecular genetics - 1 Feb 2020

Chen Guanjie, Shriner Daniel, Doumatey Ayo P, Zhou Jie, Bentley Amy R, Lei Lin, Adeyemo Adebowale, Rotimi Charles N

Abstract excerpt

OBJECTIVE: Serum uric acid is the end-product of purine metabolism and at high levels is a risk factor for several human diseases including gout and cardiovascular disease. Heritability estimates range from 0.32 to 0.63. Genome-wide association studies (GWAS) provide an unbiased approach to identify loci influencing serum uric acid. Here, we performed the first GWAS for serum uric acid in continental Africans,...

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Source

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Identifiers

PMID: 31841133
DOI: 10.1093/hmg/ddz272
PMCID: PMC7015846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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