Article
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.
Nature genetics - 1 Apr 2008
Vitart Veronique, Rudan Igor, Hayward Caroline, Gray Nicola K, Floyd James, Palmer Colin N A, Knott Sara A, Kolcic Ivana, Polasek Ozren, Graessler Juergen, Wilson James F, Marinaki Anthony, Riches Philip L, Shu Xinhua, Janicijevic Branka, Smolej-Narancic Nina, Gorgoni Barbara, Morgan Joanne, Campbell Susan, Biloglav Zrinka, Barac-Lauc Lovorka, Pericic Marijana, Klaric Irena Martinovic, Zgaga Lina, Skaric-Juric Tatjana, Wild Sarah H, Richardson William A, Hohenstein Peter, Kimber Charley H, Tenesa Albert, Donnelly Louise A, Fairbanks Lynette D, Aringer Martin, McKeigue Paul M, Ralston Stuart H, Morris Andrew D, Rudan Pavao, Hastie Nicholas D, Campbell Harry, Wright Alan F
Abstract excerpt
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared with other mammals (3-120 microM). About 70% of daily urate disposal occurs via the kidneys, and in 5-25% of the human population, impaired renal excretion leads to hyperuricemia. About 10% of people with...
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