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Article

Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization.

Science advances - 1 Dec 2019

Eastman Alison J, Xu Jintao, Bermik Jennifer, Potchen Nicole, den Dekker Aaron, Neal Lori M, Zhao Guolei, Malachowski Antoni, Schaller Matt, Kunkel Steven, Osterholzer John J, Kryczek Ilona, Olszewski Michal A

Abstract excerpt

Epigenetic modifications play critical roles in inducing long-lasting immunological memory in innate immune cells, termed trained immunity. Whether similar epigenetic mechanisms regulate dendtritic cell (DC) function to orchestrate development of adaptive immunity remains unknown. We report that DCs matured with IFNγ and TNFα or matured in the lungs during invasive fungal infection with endogenous TNFα acquired a...

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Identifiers

PMID: 31840058
DOI: 10.1126/sciadv.aaw9051
PMCID: PMC6892624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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