Article
Differential activation profiles of multiple transcription factors during dendritic cell maturation.
The Journal of investigative dermatology - 1 Apr 2005
Mizumoto Norikatsu, Hui Francis, Edelbaum Dale, Weil M Ryan, Wren Jonathan D, Shalhevet David, Matsue Hiroyuki, Liu Lei, Garner Harold R, Takashima Akira
Abstract excerpt
Immature dendritic cells (DC) at the environmental interfaces, such as the skin, constantly survey the tissue for the emergence of microbial products and pro-inflammatory mediators. Upon recognition of such "danger" signals, they undergo dynamic reprogramming of gene expression and functions, the process known as DC maturation, which plays critical roles in both innate and adaptive immune responses. Although DC...
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