Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs

Abstract excerpt

Abstract The non-pathogenic T H 17 subset of helper T cells clears fungal infections, whereas pathogenic T H 17 cells cause inflammation and tissue damage; however, the mechanisms controlling these distinct responses remain unclear. Here we found that fungi sensing by the C-type lectin dectin-1 in human dendritic cells (DCs) directed the polarization of non-pathogenic T H 17 cells. Dectin-1 signaling triggered...

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