Article

The Biological Reboot: How the Alpha-Type-1 Polarized Dendritic Cell Restores Bidirectional Immune Instruction

2026-04-15

Abstract excerpt

<h4>Background: </h4> The dendritic cell initiates and directs antigen-specific immunity. Three Nobel Prizes frame the system it controls: Steinman (2011) for the dendritic cell as conductor of adaptive immunity; Allison and Honjo (2018) for CTLA-4 and PD-1 checkpoint inhibition; Sakaguchi, Brunkow, and Ramsdell (2025) for Foxp3+ regulatory T cell tolerance. Hypothesis: The evidence reviewed here establishes that...

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Literature Corpus work: e7986fb7-6ec8-560b-b982-e60d065dc157
DOI: 10.20944/preprints202604.0868.v2

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