Article

Transcriptome profiling of pathogen-specific CD4 T cells identifies T-cell-intrinsic caspase-1 as an important regulator of Th17 differentiation

2018-10-25

Abstract excerpt

<h4>One sentence summary</h4> Our study revealed that DCs shape distinct pathogen-specific CD4 T cell transcriptome and from which, we discovered an unexpected role for T-cell-intrinsic caspase-1 in promoting Th17 differentiation. <h4>ABSTRACT</h4> Dendritic cells (DCs) are critical for priming and differentiation of pathogen-specific CD4 T cells. However, to what extent innate cues from DCs dictate transcriptio...

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Literature Corpus work: 64da2eef-02a2-5441-beca-dc3fa07632d1
DOI: 10.1101/452763

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