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Article

Therapeutic Monitoring of Circulating DNA Mutations in Metastatic Cancer with Personalized Digital PCR.

The Journal of molecular diagnostics : JMD - 1 Feb 2020

Wood-Bouwens Christina M, Haslem Derrick, Moulton Bryce, Almeda Alison F, Lee Hojoon, Heestand Gregory M, Nadauld Lincoln D, Ji Hanlee P

Abstract excerpt

As a high-performance solution for longitudinal monitoring of patients being treated for metastatic cancer, a single-color digital PCR (dPCR) assay that detects and quantifies specific cancer mutations present in circulating tumor DNA (ctDNA) was developed. This customizable assay has a high sensitivity of detection. One can detect a mutation allelic fraction of 0.1%, equivalent to three mutation-bearing DNA...

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Identifiers

PMID: 31837432
DOI: 10.1016/j.jmoldx.2019.10.008
PMCID: PMC7031679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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