Article
Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in metastatic solid tumor patients.
Oncotarget - 24 Nov 2015
Kim Seung Tae, Lee Won-Suk, Lanman Richard B, Mortimer Stefanie, Zill Oliver A, Kim Kyoung-Mee, Jang Kee Taek, Kim Seok-Hyung, Park Se Hoon, Park Joon Oh, Park Young Suk, Lim Ho Yeong, Eltoukhy Helmy, Kang Won Ki, Lee Woo Yong, Kim Hee-Cheol, Park Keunchil, Lee Jeeyun, Talasaz AmirAli
Abstract excerpt
Sequencing of the mutant allele fraction of circulating cell-free DNA (cfDNA) derived from tumors is increasingly utilized to detect actionable genomic alterations in cancer. We conducted a prospective blinded study of a comprehensive cfDNA sequencing panel with 54 cancer genes. To evaluate the concordance between cfDNA and tumor DNA (tDNA), sequencing results were compared between cfDNA from plasma and genomic...
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