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Clinical utility of longitudinal circulating tumor DNA analysis in metastatic colorectal cancer patients receiving palliative chemotherapy.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Jun 2026

Oh Chung Ryul, Lee Ji-Young, Kim Jeong Eun, Jun Ha Ra, Kim Sun Young, Kim Tae Won, Kim Jihun, Chun Sung-Min, Hong Yong Sang

Abstract excerpt

BACKGROUND: This study aims to evaluate the use of circulating tumor DNA (ctDNA) for identifying mutation profiles and monitoring dynamic changes in patients with metastatic colorectal cancer (mCRC) undergoing palliative chemotherapy. METHODS: This prospective observational study enrolled patients with mCRC treated at Asan Medical Center, Korea, between July 2018 and April 2020. ctDNA analysis was performed on...

Topics

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Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Circulating Tumor DNA
Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

Neoplasm Metastasis

Palliative Care

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 41483371
DOI: 10.1007/s12094-025-04168-6

Genes

APC
EGFR
KRAS
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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