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Article

Circulating tumor DNA: current challenges for clinical utility.

The Journal of clinical investigation - 15 Jun 2022

Dang Donna K, Park Ben H

Abstract excerpt

Cancer cells shed naked DNA molecules into the circulation. This circulating tumor DNA (ctDNA) has become the predominant analyte for liquid biopsies to understand the mutational landscape of cancer. Coupled with next-generation sequencing, ctDNA can serve as an alternative substrate to tumor tissues for mutation detection and companion diagnostic purposes. In fact, recent advances in precision medicine have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35703177
DOI: 10.1172/JCI154941
PMCID: PMC9197509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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