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Identification and Use of Personalized Genomic Markers for Monitoring Circulating Tumor DNA.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Chen Yilun, George Anthony M, Olsson Eleonor, Saal Lao H

Abstract excerpt

Digital PCR techniques are ideally suited for accurately quantifying trace amounts of target DNA sequences, such as tumor-derived mutant DNA that is present in the blood circulation of patients with cancer. Here, we describe an approach marrying low-coverage whole-genome sequencing of tumor tissues, to enumerate chromosomal rearrangement breakpoints, together with droplet digital PCR (ddPCR)-based personalized...

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PMID: 29717450
DOI: 10.1007/978-1-4939-7778-9_17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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