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Article

Transcription Factor Enrichment Analysis in Enhancers Identifies EZH2 as a Susceptibility Gene for Osteoporosis.

The Journal of clinical endocrinology and metabolism - 1 Apr 2020

Li Meng, Yao Shi, Duan Yuan-Yuan, Zhang Yu-Jie, Guo Yan, Niu Hui-Min, Dong Shan-Shan, Qiu Yu-Sheng, Yang Tie-Lin

Abstract excerpt

PURPOSE: Genome-wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with osteoporosis. Most of these SNPs are noncoding variants and could be mapped to enhancers. Transcription factors (TFs) play important roles in gene regulation via enhancers harboring these SNPs; thus, we aimed to identify common regulatory TFs binding to enhancers associated with...

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PMID: 31833556
DOI: 10.1210/clinem/dgz270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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