Article
Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis.
Human genetics - 1 Aug 2017
Yao Shi, Guo Yan, Dong Shan-Shan, Hao Ruo-Han, Chen Xiao-Feng, Chen Yi-Xiao, Chen Jia-Bin, Tian Qing, Deng Hong-Wen, Yang Tie-Lin
Abstract excerpt
Despite genome-wide association studies (GWASs) have identified many susceptibility genes for osteoporosis, it still leaves a large part of missing heritability to be discovered. Integrating regulatory information and GWASs could offer new insights into the biological link between the susceptibility SNPs and osteoporosis. We generated five machine learning classifiers with osteoporosis-associated variants and...
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