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Article

Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2018

Zhu Dong-Li, Chen Xiao-Feng, Hu Wei-Xin, Dong Shan-Shan, Lu Bing-Jie, Rong Yu, Chen Yi-Xiao, Chen Hao, Thynn Hlaing Nwe, Wang Nai-Ning, Guo Yan, Yang Tie-Lin

Abstract excerpt

RANKL is a key regulator involved in bone metabolism, and a drug target for osteoporosis. The clinical diagnosis and assessment of osteoporosis are mainly based on bone mineral density (BMD). Previous powerful genomewide association studies (GWASs) have identified multiple intergenic single-nucleotide polymorphisms (SNPs) located over 100 kb upstream of RANKL and 65 kb downstream of AKAP11 at 13q14.11 for...

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Share to Chromosomes, Human, Pair 13
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Molecular Sequence Annotation

Share to NFI Transcription Factors

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Source

Identifiers

PMID: 29528523
DOI: 10.1002/jbmr.3419

Genes

AKAP11
NFIC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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