Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The osteoporosis susceptible SNP rs4325274 remotely regulates the SOX6 gene through enhancers.

Yi chuan = Hereditas - 20 Sept 2020

Tuo Xiao Mei, Zhu Dong Li, Chen Xiao Feng, Rong Yu, Guo Yan, Yang Tie Lin

Abstract excerpt

Osteoporosis is a typical polygenic disease, and its heritability is as high as 85%. The incidence of osteoporosis has jumped to the fifth among the common diseases. Although a large number of osteoporosis-susceptible SNPs have been identified, most of them are in the non-coding regions of the genome and the functional mechanisms are unknown. The purpose of this study was to explore the function of non-coding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Osteoporosis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to SOXD Transcription Factors

Source

Identifiers

PMID: 32952123
DOI: 10.16288/j.yczz.20-098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The osteoporosis susceptible SNP rs4325274 remotely regulates the SOX6 gene through enhancers.PMID 32952123Read ↗

An Osteoporosis Susceptibility Allele at 11p15 Regulates SOX6 Expression by Modulating TCF4 Chromatin Binding.Semantic proximity Read ↗

Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies.Semantic proximity Read ↗

An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation.Semantic proximity Read ↗

The effect of SOX4 gene 3'UTR polymorphisms on osteoporosis.Semantic proximity Read ↗

Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations.Semantic proximity Read ↗

Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis.Semantic proximity Read ↗

Transcription Factor Enrichment Analysis in Enhancers Identifies EZH2 as a Susceptibility Gene for Osteoporosis.Semantic proximity Read ↗

The osteoporosis risk variant rs9820407 at 3p22.1 acts as an allele-specific enhancer to regulate CTNNB1 expression by long-range chromatin loop formation.Semantic proximity Read ↗

Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk.Semantic proximity Read ↗

The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding.Semantic proximity Read ↗

Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer.Semantic proximity Read ↗

Differential gene expression orchestrated by transcription factors in osteoporosis: bioinformatics analysis of associated polymorphism elaborating functional relationships.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.