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Ezh2 Ameliorates Osteoarthritis by Activating TNFSF13B

7 Jan 2020

Abstract excerpt

Epigenetic regulation is highly correlated with osteoarthritis (OA) development, whereas its role and detailed mechanisms remain elusive. In this study, we explored the expression of EZH2, an H3K27me3 transferase, in human OA cartilages and its roles in regulating OA pathogenesis. Here, we found EZH2 was highly expressed in both mice and human OA cartilage samples by using histological analysis and RNA sequencing...

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PMID: 31910305
DOI: 10.1002/jbmr.3952

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