Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts.

doi:10.1016/j.ajhg.2021.11.018

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Article

Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts.

American journal of human genetics - 6 Jan 2022

Suthon Sarocha, Lin Jianjian, Perkins Rachel S, Crockarell John R, Miranda-Carboni Gustavo A, Krum Susan A

Abstract excerpt

Genetic factors and estrogen deficiency contribute to the development of osteoporosis. The single-nucleotide polymorphism (SNP) rs2887571 is predicted from genome-wide association studies (GWASs) to associate with osteoporosis but has had an unknown mechanism. Analysis of osteoblasts from 110 different individuals who underwent joint replacement revealed that the genotype of rs2887571 correlates with WNT5B...

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PMID: 34906330
DOI: 10.1016/j.ajhg.2021.11.018
PMCID: PMC8764205

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