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Article

Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk.

Scientific reports - 28 Jul 2016

Guo Yan, Dong Shan-Shan, Chen Xiao-Feng, Jing Ying-Aisha, Yang Man, Yan Han, Shen Hui, Chen Xiang-Ding, Tan Li-Jun, Tian Qing, Deng Hong-Wen, Yang Tie-Lin

Abstract excerpt

To identify susceptibility genes for osteoporosis, we conducted an integrative analysis that combined epigenomic elements and previous genome-wide association studies (GWASs) data, followed by validation at population and functional levels, which could identify common regulatory elements and predict new susceptibility genes that are biologically meaningful to osteoporosis. By this approach, we found a set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27465306
DOI: 10.1038/srep30558
PMCID: PMC4964617

Genes

BDNF
SATB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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