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Article

The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2024

Wang Ya, Huang Xinyao, Zhang Qiongdan, Cheng Chen, Qin Zixuan, Lu Li, Huang Qingyang

Abstract excerpt

EN1 encodes a homeodomain-containing transcription factor and is a determinant of bone density and fracture. Previous powerful genome-wide association studies (GWASs) have identified multiple single-nucleotide polymorphisms (SNPs) near EN1 at 2q14.2 locus for osteoporosis, but the causal SNPs and functional mechanisms underlying these associations are poorly understood. The target genes regulated by the...

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PMID: 38153509
DOI: 10.1007/s00109-023-02412-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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