Article
Analysis of Cerebrospinal Fluid Soluble TREM2 and Polymorphisms in Sporadic Parkinson's Disease in a Chinese Population.
Journal of molecular neuroscience : MN - 1 Feb 2020
Peng Guoyou, Qiu Jiewen, Liu Hanqun, Zhou Miaomiao, Huang Shuxuan, Guo Wenyuan, Lin Yuwan, Chen Xiang, Li Zhe, Li Guihua, Zhang Wenlong, Zhang Yunlong, Li Xingjian, Wu Zhuohua, Wei Lei, Yang Xinling, Zhu Xiaoqin, Mo Mingshu, Xu Pingyi
Abstract excerpt
BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor that mediates the degradation disorder of amyloid β (Aβ) in Alzheimer's disease. However, the role of TREM2 in Parkinson's disease (PD) and α-Synclein (α-Syn) degradation is largely unknown. METHODS: In this case-control study on Chinese population, we sequenced for polymorphisms in exon 2 of the TREM2 gene in...
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