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Article

TREM2 variants in neurodegenerative disorders in the Polish population. Homozygosity and compound heterozygosity in FTD patients.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Aug 2018

Peplonska Beata, Berdynski Mariusz, Mandecka Monika, Barczak Anna, Kuzma-Kozakiewicz Magdalena, Barcikowska Maria, Zekanowski Cezary

Abstract excerpt

Activation of the TREM2 receptor on microglia stimulates phagocytosis and decreases the microglial proinflammatory response. Mutations in exon 2 of the TREM2 gene have been reported to be associated with various neurodegenerative diseases characterized by chronic inflammation. The aim of our study was to evaluate exon 2 of TREM2 gene variants as a putative genetic risk factor for Alzheimer's disease (AD),...

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Identifiers

PMID: 29557178
DOI: 10.1080/21678421.2018.1451894

Genes

TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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