Article
Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2020
Ghisays Valentina, Goradia Dhruman D, Protas Hillary, Bauer Robert J, Devadas Vivek, Tariot Pierre N, Lowe Val J, Knopman David S, Petersen Ronald C, Jack Clifford R, Caselli Richard J, Su Yi, Chen Kewei, Reiman Eric M
Abstract excerpt
INTRODUCTION: We previously characterized associations between brain imaging measurements of amyloid-β (Aβ) plaque burden and apolipoprotein E (APOE) ε4 gene dose in a small number of cognitively unimpaired late-middle-aged APOE ε4 homozygotes (HMs), heterozygotes (HTs), and noncarriers (NCs). We now characterize cross-sectional Aβ plaque, tau tangle, and cortical atrophy (neurodegeneration) measurements,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.