Article
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
Nature neuroscience - 1 Aug 2025
Ossenkoppele Rik, Coomans Emma M, Apostolova Liana G, Baker Suzanne L, Barthel Henryk, Beach Thomas G, Benzinger Tammy L S, Betthauser Tobey, Bischof Gérard N, Bottlaender Michel, Bourgeat Pierick, den Braber Anouk, Brendel Matthias, Brickman Adam M, Cash David M, Carrillo Maria C, Coath William, Christian Bradley T, Dickerson Brad C, Dore Vincent, Drzezga Alexander, Feizpour Azadeh, van der Flier Wiesje M, Franzmeier Nicolai, Frisoni Giovanni B, Garibotto Valentina, van de Giessen Elsmarieke, Domingo-Gispert Juan, Gnoerich Johannes, Gu Yuna, Guan Yihui, Hanseeuw Bernard J, Harrison Theresa M, Jack Clifford R, Jaeger Elena, Jagust William J, Jansen Willemijn J, La Joie Renaud, Johnson Keith A, Johnson Sterling C, Kennedy Ian A, Kim Jun Pyo, van Laere Koen, Lagarde Julien, Lao Patrick, Luchsinger José A, Kern Silke, Kreisl William C, Malotaux Vincent, Malpetti Maura, Manly Jennifer J, Mao Xiaoxie, Mattsson-Carlgren Niklas, Messerschmidt Konstantin, Minguillon Carolina, Mormino Elizabeth M, O'Brien John T, Palmqvist Sebastian, Peretti Debora E, Petersen Ron C, Pijnenburg Yolande A L, Pontecorvo Michael J, Poirier Judes, Rabinovici Gil D, Rahmouni Nesrine, Risacher Shannon L, Rosa-Neto Pedro, Rosen Howard, Rowe Christopher C, Rowe James B, Rullmann Michael, Salman Yasmine, Sarazin Marie, Saykin Andrew J, Schneider Julie A, Schöll Michael, Schott Jonathan M, Seo Sang Won, Serrano Geidy E, Shcherbinin Sergey, Shekari Mahnaz, Skoog Ingmar, Smith Ruben, Sperling Reisa A, Spruyt Laure, Stomrud Erik, Strandberg Olof, Therriault Joseph, Xie Fang, Vandenberghe Rik, Villemagne Victor L, Villeneuve Sylvia, Visser Pieter Jelle, Vossler Hillary, Young Christina B, Groot Colin, Hansson Oskar
Abstract excerpt
Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394...
