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Article

Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2009

Reiman Eric M, Chen Kewei, Liu Xiaofen, Bandy Daniel, Yu Meixiang, Lee Wendy, Ayutyanont Napatkamon, Keppler Jennifer, Reeder Stephanie A, Langbaum Jessica B S, Alexander Gene E, Klunk William E, Mathis Chester A, Price Julie C, Aizenstein Howard J, DeKosky Steven T, Caselli Richard J

Abstract excerpt

Fibrillar amyloid-beta (Abeta) is found in the brains of many cognitively normal older people. Whether or not this reflects a predisposition to Alzheimer's disease (AD) is unknown. We used Pittsburgh Compound B (PiB) PET to characterize the relationship between fibrillar Abeta burden and this predisposition in cognitively normal older people at 3 mean levels of genetic risk for AD. Dynamic PiB PET scans, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19346482
DOI: 10.1073/pnas.0900345106
PMCID: PMC2665196

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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