Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks

3 Dec 2019

Abstract excerpt

The healing of broken chromosomes by de novo telomere addition, while a normal developmental process in some organisms, has the potential to cause extensive loss of heterozygosity, genetic disease, or cell death. However, it is unclear how de novo telomere addition (dnTA) is regulated at DNA double-strand breaks (DSBs). Here, using a non-essential minichromosome in fission yeast, we identify roles for the HR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31828313
DOI: 10.1093/nar/gkz1109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaksPMID 31828313Read ↗

Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.Semantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition.Semantic proximity Read ↗

Homology-directed repair involves multiple strand invasion cycles in fission yeastSemantic proximity Read ↗

Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.Semantic proximity Read ↗

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationSemantic proximity Read ↗

DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.Semantic proximity Read ↗

RTEL1 maintains genomic stability by suppressing homologous recombination.Semantic proximity Read ↗

Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization.Semantic proximity Read ↗

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealingSemantic proximity Read ↗

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read ↗

Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.