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Article

Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization.

Genetics - 1 Nov 2018

Macaisne Nicolas, Kessler Zebulin, Yanowitz Judith L

Abstract excerpt

Double-strand breaks (DSBs) are among the most deleterious lesions DNA can endure. Yet, DSBs are programmed at the onset of meiosis, and are required to facilitate appropriate reduction of ploidy in daughter cells. Repair of these breaks is tightly controlled to favor homologous recombination (HR)-the only repair pathway that can form crossovers. However, little is known about how the activities of alternative...

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Identifiers

PMID: 30242011
DOI: 10.1534/genetics.118.301402
PMCID: PMC6218235

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