Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant pre-mRNA processing in cancer.

The Journal of experimental medicine - 4 Nov 2024

Biswas Jeetayu, Boussi Leora, Stein Eytan, Abdel-Wahab Omar

Abstract excerpt

Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within all cancer types. In this review, we described the current state of understanding of how RNA processing is dysregulated in cancer with a focus on mutations in the RNA splicing factor machinery that are highly prevalent in hematologic malignancies. We discuss the downstream effects of these mutations highlighting both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasms
Share to RNA Precursors
Share to RNA Splicing Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA Processing, Post-Transcriptional

Share to RNA Splicing

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39316554
DOI: 10.1084/jem.20230891
PMCID: PMC11448470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant pre-mRNA processing in cancer.PMID 39316554Read ↗

Pre-mRNA splicing aberrations and cancer.Semantic proximity Read ↗

Pre-mRNA splicing in cancer: the relevance in oncogenesis, treatment and drug resistance.Semantic proximity Read ↗

In Brief: (mis)splicing in disease.Semantic proximity Read ↗

Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Semantic proximity Read ↗

RNA Splicing and Cancer.Semantic proximity Read ↗

Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets.Semantic proximity Read ↗

SnapShot: Splicing Alterations in Cancer.Semantic proximity Read ↗

Misregulation of pre-mRNA alternative splicing in cancer.Semantic proximity Read ↗

Splicing dysregulation in human hematologic malignancies: beyond splicing mutations.Semantic proximity Read ↗

Roles and mechanisms of alternative splicing in cancer - implications for care.Semantic proximity Read ↗

Splicing-factor alterations in cancersSemantic proximity Read ↗

Targeting splicing abnormalities in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.