Article

The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

2023-04-11

Abstract excerpt

JTE-607 is a small molecule compound with anti-inflammation and anti-cancer activities. Upon entering the cell, it is hydrolyzed to Compound 2, which directly binds to and inhibits CPSF73, the endonuclease for the cleavage step in pre-mRNA 3′ processing. Although CPSF73 is universally required for mRNA 3′ end formation, we have unexpectedly found that Compound 2- mediated inhibition of pre-mRNA 3′ processing is se...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d74973cb-0c1d-52c3-8455-a59b34e0e76b
DOI: 10.1101/2023.04.11.536453

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machineryDOI 10.1101/2023.04.11.536453Read

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.Semantic proximity Read

Targeting CPSF73, the mRNA 3’ End Processing Endonuclease, Moves Cancer Cells Away from the Mesenchymal StateSemantic proximity Read

A pan-cancer analysis of the core pre-mRNA 3′ end processing factors, and their association with prognosis, tumor microenvironment, and potential targetsSemantic proximity Read

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.Semantic proximity Read

3' end mRNA processing: molecular mechanisms and implications for health and disease.Semantic proximity Read

Progress toward the development of the small molecule equivalent of small interfering RNA.Semantic proximity Read

C19ORF66 Broadly Escapes Virus-Induced Endonuclease Cleavage and Restricts Kaposi’s Sarcoma-Associated HerpesvirusSemantic proximity Read

CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processingSemantic proximity Read

Programmable translational inhibition by a molecular glue-oligonucleotide conjugateSemantic proximity Read

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small moleculesSemantic proximity Read

Acoziborole resistance associated mutations in trypanosome CPSF3Semantic proximity Read

Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3.Semantic proximity Read