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Article

U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation.

Molecular cell - 19 May 2016

Park Sung Mi, Ou Jianhong, Chamberlain Lynn, Simone Tessa M, Yang Huan, Virbasius Ching-Man, Ali Abdullah M, Zhu Lihua Julie, Mukherjee Siddhartha, Raza Azra, Green Michael R

Abstract excerpt

Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant and identify aberrantly processed pre-mRNAs by deep sequencing. We find that in U2AF35(S34F)-transformed cells the autophagy-related factor 7 (Atg7)...

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Identifiers

PMID: 27184077
DOI: 10.1016/j.molcel.2016.04.011
PMCID: PMC5012111

Genes

ATG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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