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Article

Acquired mutations that affect pre-mRNA splicing in hematologic malignancies and solid tumors.

Journal of the National Cancer Institute - 16 Oct 2013

Scott Linda M, Rebel Vivienne I

Abstract excerpt

The application of next-generation sequencing technologies to interrogate the genome of human hematologic malignancies is providing promising insights into their molecular etiology and into the pathogenesis of seemingly unrelated malignancies. Among the somatic mutations identified by this approach are ones that target components of the spliceosome, a ribonucleoprotein complex responsible for the...

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Share to Drug Design
Share to Hematologic Neoplasms
Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribonucleoprotein, U2 Small Nuclear

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Source

Identifiers

PMID: 24052622
DOI: 10.1093/jnci/djt257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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