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Deletion of liaR Reverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic Background

15 Sept 2015

Abstract excerpt

We have shown previously that changes in LiaFSR, a three-component regulatory system predicted to orchestrate the cell membrane stress response, are important mediators of daptomycin (DAP) resistance in enterococci. Indeed, deletion of the gene encoding the response regulator LiaR in a clinical strain of Enterococcus faecalis reversed DAP resistance (DAP-R) and produced a strain hypersusceptible to antimicrobial...

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PMID: 26369959
DOI: 10.1128/aac.01073-15

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Deletion of liaR Reverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic BackgroundPMID 26369959Read ↗

A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalisSemantic proximity Read ↗

Daptomycin resistance in <i>Enterococcus faecium</i> can be delayed by disruption of the LiaFSR stress response pathwaySemantic proximity Read ↗

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An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.Semantic proximity Read ↗

LiaX is a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in <i>Enterococcus faecium</i>Semantic proximity Read ↗

Novel regulatory logic in the antibiotic resistance response of <i>Enterococcus faecalis</i> against cell envelope targeting antibioticsSemantic proximity Read ↗

LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faeciumSemantic proximity Read ↗

Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in <i>Enterococcus faecalis</i>Semantic proximity Read ↗

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Sequential steps of daptomycin resistance in Enterococcus faecium and reversion to hypersusceptibility through IS-mediated inactivation of the liaFSR operon.Semantic proximity Read ↗

Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling.Semantic proximity Read ↗

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