Article
Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis.
Antimicrobial agents and chemotherapy - 10 Dec 2025
Darnell Rachel L, Knottenbelt Melanie K, Rose Olivia E, Cleary Caitlin S B, Todd Rose Francesca O, Hodgkinson Hannah, Wu Yuezhou, Hussein Maytham, Velkov Tony, Gebhard Susanne, Cook Gregory M
Abstract excerpt
Antimicrobial tolerance, i.e., the ability to survive despite growth inhibition, is an important precursor to the development of antimicrobial resistance. However, very little is known about the evolution of drug-induced antimicrobial tolerance. Teixobactin (TXB) is an antimicrobial peptide that targets the cell envelope precursors lipid II and lipid III in Gram-positive bacteria. We have previously shown that...
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