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Article

Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Jan 2021

Ota Yusuke, Furuhashi Kazuki, Hayashi Wataru, Hirai Nachi, Ishikawa Jinko, Nagura Osanori, Yamanaka Katsumasa, Katahashi Kazuto, Aoki Kotaro, Nagano Noriyuki, Maekawa Masato

Abstract excerpt

The emergence of daptomycin (DAP) resistant Enterococcus species has increased worldwide, but the mechanisms for DAP resistance are not fully understood. We report a case of DAP resistant Enterococcus faecalis, from a clinical sample of a patient with diabetic ulcers, after DAP therapy. Whole-genome sequencing analysis revealed that the isolate had a loss-of-function point mutation within liaX encoding...

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Identifiers

PMID: 32972829
DOI: 10.1016/j.jiac.2020.09.004

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Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling.PMID 32972829Read ↗

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