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Molecular basis of cell membrane adaptation in daptomycin-resistant Enterococcus faecalis

15 Oct 2024

Abstract excerpt

Daptomycin is a last-resort lipopeptide antibiotic that disrupts cell membrane (CM) and peptidoglycan homeostasis. Enterococcus faecalis has developed a sophisticated mechanism to avoid daptomycin killing by redistributing CM anionic phospholipids away from the septum. The CM changes are orchestrated by a 3-component regulatory system, designated LiaFSR, with a possible contribution of cardiolipin synthase (Cls)....

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PMID: 39405116
DOI: 10.1172/jci.insight.173836

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Molecular basis of cell membrane adaptation in daptomycin-resistant Enterococcus faecalisPMID 39405116Read ↗

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