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Daptomycin resistance in <i>Enterococcus faecium</i> can be delayed by disruption of the LiaFSR stress response pathway

2020-06-24

Abstract excerpt

The LiaFSR signaling pathway plays a major role in mediating daptomycin (DAP) resistance for both Enterococcus faecalis and Enterococcus faecium . LiaFSR inhibition induces DAP hypersusceptibility but could also potentially delay the acquisition of DAP resistance in a combinatorial therapy of DAP with a LiaFSR inhibitor. To evaluate the potential efficacy of this approach, the adaptation to DAP by both E. faeca...

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Literature Corpus work
7061b0e4-5d87-5f64-b36c-c22f3d22fab8
DOI
10.1101/2020.06.23.168401
Open publication

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Daptomycin resistance in <i>Enterococcus faecium</i> can be delayed by disruption of the LiaFSR stress response pathwayDOI 10.1101/2020.06.23.168401
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