Article
Germline MUTYH Mutation in a Pediatric Cancer Survivor Developing a Secondary Malignancy.
Journal of pediatric hematology/oncology - 1 Oct 2020
Lavergne Vincent, Sabnis Amit, Tupule Asmin, Davidson Philip R, Kline Cassie, Matthay Katherine, Nicolaides Theodore, Goldsby Robert, Braunstein Steve, Fogh Shannon E, Sneed Penny K, Menzel Paul, Nakamura Alice, DuBois Steven G, Haas-Kogan Daphne A, Nakamura Jean L
Abstract excerpt
Radiotherapy-induced second malignant neoplasms (SMNs) are a severe late complication in pediatric cancer survivors. Germline mutations in tumor suppressor genes contribute to SMNs; however, the most relevant germline variants mediating susceptibility are not fully defined. The authors performed matched whole-exome sequencing analyses of germline and tumor DNA from 4 pediatric solid tumor survivors who...
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