Article
Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jul 2018
Wang Zhaoming, Wilson Carmen L, Easton John, Thrasher Andrew, Mulder Heather, Liu Qi, Hedges Dale J, Wang Shuoguo, Rusch Michael C, Edmonson Michael N, Levy Shawn, Lanctot Jennifer Q, Caron Eric, Shelton Kyla, Currie Kelsey, Lear Matthew, Patel Aman, Rosencrance Celeste, Shao Ying, Vadodaria Bhavin, Yergeau Donald, Sapkota Yadav, Brooke Russell J, Moon Wonjong, Rampersaud Evadnie, Ma Xiaotu, Chang Ti-Cheng, Rice Stephen V, Pepper Cynthia, Zhou Xin, Chen Xiang, Chen Wenan, Jones Angela, Boone Braden, Ehrhardt Matthew J, Krasin Matthew J, Howell Rebecca M, Phillips Nicholas S, Lewis Courtney, Srivastava Deokumar, Pui Ching-Hon, Kesserwan Chimene A, Wu Gang, Nichols Kim E, Downing James R, Hudson Melissa M, Yasui Yutaka, Robison Leslie L, Zhang Jinghui
Abstract excerpt
Purpose Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed the contribution of pathogenic/likely pathogenic (P/LP) mutations in cancer predisposition genes to their SN risk. Patients and Methods Whole-genome sequencing (30-fold) was performed on samples from childhood cancer survivors who were ≥ 5 years since...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.