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Article

Germline rare variants in cancer susceptibility genes and subsequent neoplasm risk after childhood cancer.

Journal of the National Cancer Institute - 1 Dec 2025

Zamani Shahriar A, Karyadi Danielle M, Hartley Stephen W, Gibson Todd M, Sampson Joshua N, Kraft Peter, Chanock Stephen J, Morton Lindsay M

Abstract excerpt

BACKGROUND: Among childhood cancer survivors, germline rare variants in autosomal dominant cancer susceptibility genes could increase the risk of subsequent neoplasms, but risks for rarer subsequent neoplasms and by age at onset are not well understood. METHODS: We pooled the Childhood Cancer Survivor Study and St Jude Lifetime Cohort (median follow-up = 29.7 years [range = 7.1-55.6 years]) to identify rare...

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Identifiers

PMID: 40924783
DOI: 10.1093/jnci/djaf260
PMCID: PMC12628269

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