Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study.

doi:10.1200/JCO-25-00542

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Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2025

Zhou Liting, Singh Purnima, Crossman David, Richman Joshua, Trainor Patrick, Cheng Changde, Wang Xuexia, Sharafeldin Noha, Hageman Lindsey, Sheikh Maryam, Richard Melissa A, Friedman Danielle N, Neglia Joseph P, Wang Zhaoming, Hudson Melissa M, Armenian Saro H, Hawkins Douglas, Bhatia Ravi, Landier Wendy, Bhatia Smita

Abstract excerpt

PURPOSE: There is emerging evidence that germline pathogenic/likely pathogenic (P/LP) mutations in cancer predisposition genes (CPGs) increase the risk of subsequent neoplasms (SNs) in childhood cancer survivors. However, clinical application of this observation is hampered by the lack of knowledge regarding subpopulations at risk for SNs who could potentially benefit from genetic screening. PATIENTS AND METHODS:...

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PMID: 40829087
DOI: 10.1200/JCO-25-00542
PMCID: PMC12367065

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RB1
TP53

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