Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors.

doi:10.1158/1078-0432.CCR-16-0610

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Article

Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2017

Sherborne Amy L, Lavergne Vincent, Yu Katharine, Lee Leah, Davidson Philip R, Mazor Tali, Smirnoff Ivan V, Horvai Andrew E, Loh Mignon, DuBois Steven G, Goldsby Robert E, Neglia Joseph P, Hammond Sue, Robison Leslie L, Wustrack Rosanna, Costello Joseph F, Nakamura Alice O, Shannon Kevin M, Bhatia Smita, Nakamura Jean L

Abstract excerpt

Purpose: Second malignant neoplasms (SMNs) are severe late complications that occur in pediatric cancer survivors exposed to radiotherapy and other genotoxic treatments. To characterize the mutational landscape of treatment-induced sarcomas and to identify candidate SMN-predisposing variants, we analyzed germline and SMN samples from pediatric cancer survivors.Experimental Design: We performed whole-exome...

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Identifiers

PMID: 27683180
DOI: 10.1158/1078-0432.CCR-16-0610
PMCID: PMC5570538

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