Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues.

Cancer discovery - 3 Jun 2024

Sánchez-Guixé Mònica, Muiños Ferran, Pinheiro-Santin Morena, González-Huici Víctor, Rodriguez-Hernandez Carlos J, Avgustinova Alexandra, Lavarino Cinzia, González-Pérez Abel, Mora Jaume, López-Bigas Núria

Abstract excerpt

Pediatric cancers are rare diseases, and children without known germline predisposing conditions who develop a second malignancy during developmental ages are extremely rare. We present four such clinical cases and, through whole-genome and error-correcting ultra-deep duplex sequencing of tumor and normal samples, we explored the origin of the second malignancy in four children, uncovering different routes of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to High-Throughput Nucleotide Sequencing

Share to Infant

Share to Leukemia, Myeloid, Acute

Share to Neoplasms, Second Primary

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 38501975
DOI: 10.1158/2159-8290.CD-23-1186
PMCID: PMC11145171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues.PMID 38501975Read ↗

Prevalence of pathogenic variants in cancer-predisposing genes in second cancer after childhood solid cancers.Semantic proximity Read ↗

Genetic Risk of Second Malignant Neoplasm after Childhood Cancer Treatment: A Systematic Review.Semantic proximity Read ↗

Developmental origins shape the paediatric cancer genome.Semantic proximity Read ↗

Therapy-Related Mutational Signatures in Subsequent Neoplasms among Survivors of Childhood Cancer.Semantic proximity Read ↗

The Mutational Epidemiology of Childhood Cancer.Semantic proximity Read ↗

Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms.Semantic proximity Read ↗

Genomics of Subsequent Neoplasms in Childhood Cancer Survivors.Semantic proximity Read ↗

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid NeoplasmsSemantic proximity Read ↗

The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms.Semantic proximity Read ↗

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.Semantic proximity Read ↗

Toward a Unified Theory of Why Young People Develop Cancer.Semantic proximity Read ↗

DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade ToxicitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.