Article
Pathogenic Variants in Adult-Onset Cancer Predisposition Genes in Pediatric Cancer: Prevalence and Impact on Tumor Molecular Features and Clinical Management.
Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Apr 2023
McGee Rose B, Oak Ninad, Harrison Lynn, Xu Ke, Nuccio Regina, Blake Alise K, Mostafavi Roya, Lewis Sara, Taylor Leslie M, Kubal Manish, Ouma Annastasia, Hines-Dowell Stacy J, Cheng Cheng, Furtado Larissa V, Nichols Kim E
Abstract excerpt
PURPOSE: Clinical genomic sequencing of pediatric tumors is increasingly uncovering pathogenic variants in adult-onset cancer predisposition genes (aoCPG). Nevertheless, it remains poorly understood how often aoCPG variants are of germline origin and whether they influence tumor molecular profiles and/or clinical care. In this study, we examined the prevalence, spectrum, and impacts of aoCPG variants on tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.