Article
Therapy-Related Mutational Signatures in Subsequent Neoplasms among Survivors of Childhood Cancer.
Cancer discovery - 3 Aug 2026
Brady Samuel W, Arnold Michael A, Wang Mingjuan, Alsallaq Ramzi, Dong Li, Khan Mohammad Aslam, Yang Wentao, Stratton Kayla L, Liu Wei, Chen Yan, Plyler Emily, Steele Jacob A, Powers Brent B, Rosenfeld David, Edmonson Michael N, Feng Yuan, Terekhanova Nadezhda V, Hagiwara Kohei, Arunachalam Sasi, Mulder Heather L, Srivastava Deo Kumar, Rusch Michael, Nolan Vikki G, McDonald Aaron, Sapkota Yadav, Gramatges Maria M, Turcotte Lucie M, Im Cindy, Howell Rebecca M, Easton John, Ma Xiaotu, Wang Zhaoming, Leisenring Wendy M, Conces Miriam, Neglia Joseph P, Yasui Yutaka, Bhatia Smita, Ellison David W, Zhang Jinghui, Armstrong Gregory T
Abstract excerpt
Childhood cancer survivors have a heightened risk of developing subsequent neoplasms (SN) related to therapy. We analyzed whole-genome, exome, and RNA sequencing of 200 breast, meningioma, and thyroid SNs, which developed a median of 26.4 years after childhood cancer, among 160 survivors. Meningioma and thyroid SNs were enriched for driver gene rearrangements compared with de novo tumors, including NF2-disrupting...
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