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Article

Toward a Unified Theory of Why Young People Develop Cancer.

Cold Spring Harbor perspectives in medicine - 1 Oct 2024

Kentsis Alex

Abstract excerpt

Epidemiologic and genetic studies have now defined specific patterns of incidence and distinct molecular features of cancers in young versus aging people. Here, I review a general framework for the causes of cancer in children and young adults by relating somatic genetic mosaicism and developmental tissue mutagenesis. This framework suggests how aging-associated cancers such as carcinomas, glioblastomas, and...

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Identifiers

PMID: 38692742
DOI: 10.1101/cshperspect.a041658
PMCID: PMC11444251

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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