Article
Genetic variants that associate with cirrhosis have pleiotropic effects on human traits.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2020
Chen Vincent L, Chen Yanhua, Du Xiaomeng, Handelman Samuel K, Speliotes Elizabeth K
Abstract excerpt
BACKGROUND AND AIMS: Cirrhosis is characterized by extensive fibrosis of the liver and is a major cause of liver-related mortality. Cirrhosis is partially heritable but genetic contributions to cirrhosis have not been systemically explored. Here, we carry out association analyses with cirrhosis in two large biobanks and determine the effects of cirrhosis associated variants on multiple human disease/traits....
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