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Article

Clinical Setting Modulates the Association Between Genetic Variants and Fibrosis Severity Across the Spectrum of MASLD.

Liver international : official journal of the International Association for the Study of the Liver - 1 Jun 2026

Lee Mei-Hsuan, Stepanova Maria, Estep Michael, You Yan-Ling, Liu Xia-Rong, de Avila Leyla, Lam Brian, Yu Ming-Lung, Younossi Zobair M

Abstract excerpt

BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease worldwide. Although genetic variants are linked to MASLD progression, whether their associations with fibrosis severity are consistent across clinical contexts remains unclear. METHODS: A cross-sectional analysis of 6446 individuals with MASLD from a community-based (n = 4477) and a...

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Source

Identifiers

PMID: 42093660
DOI: 10.1111/liv.70675

Genes

PNPLA3
MBOAT7
TM6SF2

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Clinical Setting Modulates the Association Between Genetic Variants and Fibrosis Severity Across the Spectrum of MASLD.PMID 42093660Read ↗

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