Monogenic and Polygenic Risk in Common Liver Diseases: Implications for Clinical Care.

doi:10.1053/j.gastro.2026.03.020

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Article

Monogenic and Polygenic Risk in Common Liver Diseases: Implications for Clinical Care.

Gastroenterology - 1 Aug 2026

Ajmera Veeral, Huang Daniel Q, Chen Vincent L, Reddy K Rajender

Abstract excerpt

The burden of chronic liver disease is rapidly increasing worldwide, driven primarily by metabolic dysfunction-associated steatotic liver disease, metabolic and alcohol-associated liver disease (MetALD), and alcohol-associated liver disease (ALD). Genetic predisposition contributes substantially to variability in disease onset, progression, and outcomes, and recent advances in genomic discovery have brought...

Topics

Humans
Genetic Risk Score
Genetic Predisposition to Disease
Acyltransferases
Phospholipases A2, Calcium-Independent
Membrane Proteins
Risk Factors
Genetic Testing
Liver Diseases
Risk Assessment
Disease Progression
Lipase
Phenotype
Multifactorial Inheritance
17-Hydroxysteroid Dehydrogenases
Fatty Liver

Source

Open in PubMed

Identifiers

PMID: 41932449
DOI: 10.1053/j.gastro.2026.03.020

Genes

HSD17B13
PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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